Sonophoresis smartpatch for pain-free, controllable, and wearable transdermal drug delivery

Introduction

Wearable SmartPatch is a unique needle-free drug delivery solution, based on a patented electronic system, that opens skin pores temporarily to deliver macromolecular drugs.

Technology Overview

It generates sound waves (Sonophoresis) that increase the size of the skin pores without pain or damage. This technology allows drugs like insulin, heparin, or EPO (>50KDa) to pass through, reaching the hypodermis and capillary vessels, without altering the pharmacokinetic profile of the drug.

Device Components

The SmartPatch consists of two main parts:

1. Durable Component:

   • Includes the ultrasound generator, electronics, and battery.
   • Comes with a 3-year warranty.

2. Disposable Component:

   • Encloses the adhesive and the drug reservoir with up to 2mL (average for 3 days of treatment).
   • Can be changed in less than 2 minutes.
   • Is recyclable.

Customization and Performance

The device can vary both the absorption rate and the depth reached depending on programmed stimulation parameters. This feature allows adaptation to different skin types and therapeutic uses.

Testing Results

Our tests have shown absorption rates of at least 0.05 mL/minute on a 1 cm² pig skin area.