SubsidieMeestersFast, easy diagnostics for personalised phage therapy
Vésale Bioscience's Phagogram is an automated diagnostic tool that rapidly identifies effective bacteriophages for personalized phage therapy, reducing testing time from days to hours.
Projectdetails
Introduction
Personalised phage therapy using magistral preparations of phages is among the most promising solutions to fight antimicrobial resistant infections. However, this approach requires a rapid diagnostic that identifies the pathogen(s) involved in the infection and the phages active on them.
Development of Phagogram
Vésale Bioscience has developed the “Phagogram,” the first automated in-vitro diagnostic tool that enables a fast determination of bacteriophages suitable for treating a particular bacterial infection.
Components of Phagogram
The Phagogram consists of:
- A basic test kit (a disposable well plate with reagents)
- A high-performance luminometer
- Dedicated software that proposes the best matching phage cocktail to treat the patient
Advantages Over Current Methodologies
Compared to the current diagnostic methodologies, which take up to 4-7 days, the Phagogram offers significant advantages:
- It compares the activity of up to 96 phages on a bacterial culture within 2-3 hours.
- It makes phage susceptibility testing accessible for hospital microbiology labs.
- It enables personalized therapy on a routine basis.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 1.800.000 |
| Totale projectbegroting | € 3.104.962 |
Tijdlijn
| Startdatum | 1-2-2023 |
| Einddatum | 31-10-2025 |
| Subsidiejaar | 2023 |
Partners & Locaties
Projectpartners
- VESALE BIOSCIENCE SPRLpenvoerder
Land(en)
Vergelijkbare projecten binnen EIC Accelerator
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
in silico bio-evolutio - novel AI paradigm for molecular biologyThis project aims to accelerate phage therapy by using an AI platform for in silico simulations to optimize phage selection, reducing experimental time and enhancing personalized treatment effectiveness. | EIC Accelerator | € 1.692.596 | 2023 | Details |
World’s first diagnostic test that can detect all bacterial species in a single assayInbiome aims to implement the "Molecular Culture" diagnostic test in hospitals to accurately identify bacterial infections within 4 hours, enhancing treatment and reducing costs. | EIC Accelerator | € 2.499.999 | 2023 | Details |
Breakthrough dual-action OTC tablet for treatment and prevention of both bacterial and fungal vaginitisGedea aims to commercialize pHyph, an antimicrobial-free pessary for treating and preventing BV and VVC, addressing a significant medical need while avoiding antibiotic resistance. | EIC Accelerator | € 2.499.999 | 2024 | Details |
Commercialisation and scale up of a Vaginal Microbiome Screening service with a menstrual tampon collection device and a digital layer to provide diagnosis, disease risk evaluation and aftercare.VMS is a home-based gynaecological test kit that uses tampons for accurate STI and HPV screening, offering comprehensive aftercare and insights into vaginal health. | EIC Accelerator | € 2.499.999 | 2023 | Details |
in silico bio-evolutio - novel AI paradigm for molecular biology
This project aims to accelerate phage therapy by using an AI platform for in silico simulations to optimize phage selection, reducing experimental time and enhancing personalized treatment effectiveness.
World’s first diagnostic test that can detect all bacterial species in a single assay
Inbiome aims to implement the "Molecular Culture" diagnostic test in hospitals to accurately identify bacterial infections within 4 hours, enhancing treatment and reducing costs.
Breakthrough dual-action OTC tablet for treatment and prevention of both bacterial and fungal vaginitis
Gedea aims to commercialize pHyph, an antimicrobial-free pessary for treating and preventing BV and VVC, addressing a significant medical need while avoiding antibiotic resistance.
Commercialisation and scale up of a Vaginal Microbiome Screening service with a menstrual tampon collection device and a digital layer to provide diagnosis, disease risk evaluation and aftercare.
VMS is a home-based gynaecological test kit that uses tampons for accurate STI and HPV screening, offering comprehensive aftercare and insights into vaginal health.
Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
Advancing Phage Therapy through Synergistic Strategies: Phage-Mediated Killing and Competitive Exclusion using Engineered ProphagesPHAGE-PRO aims to revolutionize phage therapy by utilizing engineered prophages and probiotics for rapid pathogen targeting and sustained efficacy, enhancing infection management in livestock and human medicine. | ERC Starting... | € 1.500.000 | 2025 | Details |
Rapid chip-based detection of antibiotic resistancesDeveloping ResisCHIP, a rapid RNA diagnostic tool for bacterial infections, to enhance treatment selection and combat antimicrobial resistance within 2 hours from blood samples. | ERC Proof of... | € 150.000 | 2022 | Details |
Antibioticum efficïentie testapparaat voor gepersonaliseerde patiëntenzorgDit project ontwikkelt een apparaat voor snelle, gepersonaliseerde antibioticabehandeling bij urineweginfecties, ter verbetering van patiëntenzorg. | Mkb-innovati... | € 18.421 | 2021 | Details |
Phage infection of bacterial biofilmThis project aims to characterize the dynamics of Herelleviridae phage phi812 in Staphylococcus aureus biofilms to enhance phage therapy effectiveness against antibiotic-resistant infections. | ERC Consolid... | € 1.992.976 | 2023 | Details |
Microfluïde assay on-a-chip voor detectie bacteriële infectiesLevels Diagnostics en Digi.Bio ontwikkelen een innovatieve lab-on-a-chip test voor snelle en betrouwbare differentiatie tussen virale en bacteriële luchtweginfecties om onnodig antibioticagebruik te verminderen. | Mkb-innovati... | € 180.528 | 2018 | Details |
Advancing Phage Therapy through Synergistic Strategies: Phage-Mediated Killing and Competitive Exclusion using Engineered Prophages
PHAGE-PRO aims to revolutionize phage therapy by utilizing engineered prophages and probiotics for rapid pathogen targeting and sustained efficacy, enhancing infection management in livestock and human medicine.
Rapid chip-based detection of antibiotic resistances
Developing ResisCHIP, a rapid RNA diagnostic tool for bacterial infections, to enhance treatment selection and combat antimicrobial resistance within 2 hours from blood samples.
Antibioticum efficïentie testapparaat voor gepersonaliseerde patiëntenzorg
Dit project ontwikkelt een apparaat voor snelle, gepersonaliseerde antibioticabehandeling bij urineweginfecties, ter verbetering van patiëntenzorg.
Phage infection of bacterial biofilm
This project aims to characterize the dynamics of Herelleviridae phage phi812 in Staphylococcus aureus biofilms to enhance phage therapy effectiveness against antibiotic-resistant infections.
Microfluïde assay on-a-chip voor detectie bacteriële infecties
Levels Diagnostics en Digi.Bio ontwikkelen een innovatieve lab-on-a-chip test voor snelle en betrouwbare differentiatie tussen virale en bacteriële luchtweginfecties om onnodig antibioticagebruik te verminderen.