SubsidieMeestersAdpative DBS
AlphaDBS enhances DBS treatment for Parkinson's by using adaptive stimulation based on local field potentials to optimize energy delivery in real-time.
Projectdetails
Introduction
Differently from other DBS systems on the market, the AlphaDBS can be programmed with two different types of stimulation:
Types of Stimulation
- Conventional DBS: This is implemented also by other DBS systems.
- Adaptive DBS (aDBS): This type automatically adjusts the energy delivered to the patient using a biosignal, local field potential (LFP), in a closed-loop configuration.
Local Field Potentials (LFP)
LFPs represent the synchronous presynaptic and postsynaptic activity of neuronal populations and can be recorded with the macro-electrodes routinely implanted for conventional DBS (cDBS).
Relevance in Parkinson Disease
In Parkinson Disease, LFPs (especially in the beta-band) are specifically modulated by:
- Dopamine intake
- Movement execution and preparation
Additionally, they encode non-motor functions, such as decision making.
Adaptive Algorithm
The beta band power represents the input variable to the adaptive algorithm, implemented by the AlphaDBS system, which computes a new stimulation value every second.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 2.499.999 |
| Totale projectbegroting | € 3.725.437 |
Tijdlijn
| Startdatum | 1-3-2023 |
| Einddatum | 28-2-2025 |
| Subsidiejaar | 2023 |
Partners & Locaties
Projectpartners
- NEWRONIKA SPApenvoerder
Land(en)
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