SubsidieMeestersA breakthrough active immunotherapy for the treatment of osteoarthritis
Peptinov aims to halt osteoarthritis progression through a cost-effective immunotherapy that neutralizes IL-6, with promising Phase I results leading to a Phase II trial for out-licensing readiness.
Projectdetails
Introduction
Osteoarthritis is a debilitating disease affecting the joints and is a leading cause of disability worldwide. It affects at least 250 million people and incurs healthcare costs of toward 0.5% of the GDP.
Project Overview
Peptinov is developing an active immunotherapy that can halt inflammation-driven destruction of the cartilage in the joints. We use a unique approach to neutralize a key pro-inflammatory protein (IL-6) driving chronic inflammation.
Mechanism of Action
Our vaccine-like approach stimulates the patient’s own immune system to produce antibodies against excess IL-6 and neutralize its biological function. By doing so, we aim to halt disease progression.
Cost Efficiency
Our treatment will cost 5-10% of conventional immunotherapies as we inject patients with inexpensive, immunogenic peptides to stimulate the production of endogenous antibodies.
Clinical Trials
Phase I clinical trial yielded very encouraging preliminary safety and tolerability data on 24 patients. This project will implement the Phase II clinical trial and make our therapy out-licensing ready.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 2.499.999 |
| Totale projectbegroting | € 3.965.000 |
Tijdlijn
| Startdatum | 1-3-2024 |
| Einddatum | 28-2-2026 |
| Subsidiejaar | 2024 |
Partners & Locaties
Projectpartners
- PEPTINOVpenvoerder
Land(en)
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IntraVenous Immune Boost
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Vergelijkbare projecten uit andere regelingen
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|---|---|---|---|---|
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In Silico Trials for Cartilage Regenerative Medicine ApplicationsThe INSTAnt CARMA project aims to develop and validate a multiscale in silico model for osteoarthritis to optimize drug and tissue-engineered therapies through virtual trials. | ERC Consolid... | € 2.212.385 | 2023 | Details |
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INTELLECTUALSDit project ontwikkelt een innovatief kraakbeen-op-een-chip model voor gepersonaliseerde behandelingen van osteoartritis. | 1.1 - Het ve... | € 479.529 | 2024 | Details |
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Development of a Complete Triple Action Injectable Treatment for Osteoarthritis
Relevium Ltd aims to validate and commercialize Hydrobloc, a unique therapy that regenerates cartilage, alleviates pain, and improves joint function in osteoarthritis patients.
In Silico Trials for Cartilage Regenerative Medicine Applications
The INSTAnt CARMA project aims to develop and validate a multiscale in silico model for osteoarthritis to optimize drug and tissue-engineered therapies through virtual trials.
Disruptive Therapies for the long-term relief of Osteoarthritis Pain
The Arth-Alleve project aims to develop a non-pharmaceutical, long-term therapy using neurotoxin-loaded hydrogels to effectively manage chronic pain in osteoarthritis patients, improving their quality of life.
INTELLECTUALS
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Patiënt specifieke immunotherapie voor de behandeling van alvleesklierkanker
De ontwikkeling van een gepersonaliseerde immunotherapie voor alvleesklierkanker om de overlevingskansen van patiënten te verbeteren.