SubsidieMeestersDevelopment & demonstration of low environmental impact innovation and optimization practices in pharma production
LIFE-GREENAPI aims to revolutionize API production in Europe by implementing flow-chemistry to enhance sustainability, reduce environmental impact, and support the pharmaceutical sector's decarbonization efforts.
Projectdetails
Introduction
LIFE-GREENAPI aims at proposing a technological shift in Active Pharmaceutical Ingredients (APIs) production, enabling sustainability of the European Pharmaceutical Sector, which is recognized as being one of the most difficult sectors to decarbonize, given the stringent regulatory limits.
Collaboration and Development
Angelini Pharma, in collaboration with the University of Leiden, will engineer, test, scale-up, and demonstrate at an industrial level the environmental benefit of an innovative approach for the manufacturing of APIs, switching from batch to flow-chemistry.
Implementation Strategy
The technological innovation will be first developed and tested on a selected high-production volume API (400 t/y in Europe), and then replicated on two additional small molecules, in order to demonstrate the broad spectrum of applicability.
Expected Environmental Impacts
The novel approach is expected to lead to important environmental impacts:
- Reduction in use of dangerous chemicals: 6.5 tons initially, expected to become more than 473 tons/y after 5 years of replication.
- Energy consumption reduction: 33%, corresponding to 5 MWh saved in the 3-year project and 360 MWh/y after 5 years from the project end.
- Reduction of inappropriately managed waste: More than 10 tons, leading to 714 tons/y after 5 years.
- Reduction of water usage: More than 880 m³, equating to 64,192 m³/y after 5 years.
- CO2eq overall reduction: Equal to 31 tCO2eq within the project duration and 2,230 tCO2eq/y after 5 years.
Market Impact and Stakeholder Involvement
LIFE-GREENAPI is bringing to the EU market a concrete way to support pharma industries in their journey towards net-zero emissions: a very difficult goal for such a strictly regulated sector.
Future Adoption
LIFE-GREENAPI will involve several stakeholders from the Pharma business in Europe and will pave the way for the broad adoption of the flow-chemistry technology in APIs manufacturing. It will demonstrate the real savings, both from environmental and economic perspectives, through a full Life Cycle Assessment (LCA) and risk assessment that will be performed on the whole production process.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 1.516.536 |
| Totale projectbegroting | € 2.527.561 |
Tijdlijn
| Startdatum | 1-6-2023 |
| Einddatum | 31-5-2026 |
| Subsidiejaar | 2023 |
Partners & Locaties
Projectpartners
- AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO - A.C.R.A.F. - SPApenvoerder
- UNIVERSITEIT LEIDEN
Land(en)
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