Micro-Macro Secure Control of Infinite-Dimensional Transport Systems
C-NORA aims to develop a holistic framework for efficient control design and analysis of complex biological transport systems to improve epidemic suppression and blood transport monitoring.
Projectdetails
Introduction
Although "transport" may imply different notions for different scientific fields, the feature of incorporation of interacting system components through which "information" is propagated remains invariant. Biological transport systems is an example whose significance has become evident with the recent outbreak of COVID-19 spreading. Blood transport in cardiovascular systems falls also under this category.
Urgent Need for Efficient Strategies
The urgent need for the design of efficient/safe epidemic spreading suppression and congested blood transport monitoring strategies is apparent, considering the potential significant socioeconomic impact.
Challenges in Development
However, the continuum, spatiotemporally-varying nature of such interconnected systems, in addition to dynamic complexity and limited available control authority, hampers the development of systematic feedback control design and analysis methodologies.
C-NORA Framework
C-NORA aims at the introduction of a pioneering holistic framework for systematic, computationally tractable control design and analysis of large-scale, interacting, distributed parameter transport systems, which:
- Harmonizes control at micro-macro levels.
- Accounts in design for all essential dynamic phenomena.
- Compensates adverse effects of limited control authority in design.
- Develops ad hoc tools for system-specific analysis.
Demonstration and Validation
C-NORA's new control design and analysis tools will be demonstrated in distributed parameter, epidemiological/cardiovascular transport systems and will be validated in numerical simulation.
Risks and Scientific Gain
C-NORA's high risk lies in the unification and complexity of heterogeneous, unexplored infinite-dimensional systems, whose treatment requires rethinking of fundamental control-theoretic tools.
C-NORA's high scientific gain lies in that, on the way of executing its key ideas, novel, interdisciplinary concepts and groundbreaking control/analysis methodologies will be introduced, while unprecedented research arenas will open for systems and control, transport, mathematicians, and systems biologists.
Financiële details & Tijdlijn
Financiële details
Subsidiebedrag | € 2.000.000 |
Totale projectbegroting | € 2.000.000 |
Tijdlijn
Startdatum | 1-12-2023 |
Einddatum | 30-11-2028 |
Subsidiejaar | 2023 |
Partners & Locaties
Projectpartners
- POLYTECHNEIO KRITISpenvoerder
Land(en)
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Scalable Control Approximations for Resource Constrained Environments
This project aims to advance optimal control and decision-making for nonlinear processes on dynamic networks by developing new theories, algorithms, and software for various applications.
Scalable systems modelling to simulate body-level interplays among non-communicable diseases
O-Health aims to develop a modular ecosystem of multiscale computational models for non-communicable diseases, integrating systemic communications and real-world data to enhance understanding and treatment.
Projection-based Control: A Novel Paradigm for High-performance Systems
PROACTHIS aims to develop a novel projection-based control paradigm to enhance performance in future engineering systems through innovative design and optimization techniques.
ADAPTIVE TRANSPORT SYSTEMS WITH HOLISTIC REPRESENTATION OF SUPPLY AND DEMAND
ADAPT-OR aims to develop a self-learning adaptive modeling framework for transportation systems, enhancing efficiency and sustainability by integrating supply and demand decision-making.
New methodologies for automated modeling of the dynamic behavior of large biological networks
AUTOMATHIC aims to develop an automated framework for ODE modeling of cell transport and signaling to enhance drug safety and optimize therapies for chronic kidney disease patients.
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