SubsidieMeestersImproving Kidney Health by Targeting Urinary Biomarkers for Tubular Function
U-Tube aims to identify urinary biomarkers for tubular function to enable early detection and treatment of progressive chronic kidney disease, improving patient outcomes.
Projectdetails
Introduction
Chronic kidney disease (CKD) affects one in ten people worldwide and is often progressive. Progressive CKD not only causes kidney failure, but also premature aging, cardiovascular disease, and loss of quality of life. Currently, progressive CKD can only be diagnosed after irreversible damage to the kidney has already occurred. There is therefore an urgent need for earlier biomarkers.
Current Diagnosis Challenges
The kidney consists of filters and tubules, but diagnosis of progressive CKD is currently based on filter function alone. This is surprising, as it is tubular injury that drives CKD progression, and it is the tubule that is targeted by recently developed kidney-protective treatments.
Project Aim
U-Tube therefore aims to identify and apply next-generation biomarkers for kidney tubular function to facilitate the early detection and treatment of progressive CKD.
Central Hypothesis
My central hypothesis is that the factors that cause tubular injury and CKD progression are present in urine and therefore detectable as biomarkers.
Research Focus
I will focus on urinary microcrystals and extracellular vesicles (EVs) as the drivers of tubular injury, which I will first study in tubuloids using a multi-omics approach.
Large-Scale Analysis
Subsequently, I will perform a large-scale analysis of crystallization and EVs in urine samples from people with stable or progressive CKD. I will then single out those biomarkers that can be targeted by kidney-protective treatment.
Development of a Tubular Panel
These targetable biomarkers will be moved forward for the development of a high-throughput tubular panel that I will test for its potential to predict progressive CKD, compared to a gold standard test for tubular function.
Innovations and Impact
U-Tube will use cutting-edge innovations to identify urinary biomarkers for tubular function that are targetable and implementable in clinical practice. If successful, it will advance the prediction of CKD progression and, as such, redefine how we assess kidney health.
Conclusion
By enabling early kidney-protective treatment, U-Tube has the potential to vastly improve CKD outcomes.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 2.000.000 |
| Totale projectbegroting | € 2.000.000 |
Tijdlijn
| Startdatum | 1-6-2024 |
| Einddatum | 31-5-2029 |
| Subsidiejaar | 2024 |
Partners & Locaties
Projectpartners
- ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAMpenvoerder
Land(en)
Vergelijkbare projecten binnen European Research Council
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
Identification of novel diagnostic, predictive and therapeutic strategies in chronic kidney diseaseTargetCKD aims to revolutionize chronic kidney disease management by developing noninvasive diagnostics and novel therapeutics through advanced genomic technologies and interdisciplinary research. | ERC Consolid... | € 1.999.063 | 2022 | Details |
Early detection, molecular mechanisms and therapeutic interventions in chronic kidney diseaseELIMINATE-CKD aims to enhance chronic kidney disease detection by developing a method to quantify nephron number using multi-omics and machine learning for improved diagnostics and therapies. | ERC Consolid... | € 2.000.000 | 2024 | Details |
Functional Measurements IN-THE-KIDNEY to Diagnose, Understand and Treat Renal TubulopathiesThis project aims to develop urine-based diagnostics and patient-specific models to enhance understanding and treatment of magnesium-wasting renal tubulopathies through innovative functional studies. | ERC Starting... | € 1.500.000 | 2022 | Details |
Deciphering the genetic basis of chronic kidney disease towards prevention and personalized therapyThis project aims to uncover the genetic basis of chronic kidney disease (CKD) through next-generation sequencing and develop RNA-based therapies for targeted treatment and improved management. | ERC Starting... | € 1.800.000 | 2022 | Details |
Decoding diabetic kidney diseaseDECODE-DKD aims to identify novel drug targets for diabetic kidney disease through patient-centric multi-omic research and in-vitro models, advancing precision medicine and treatment options. | ERC Starting... | € 1.783.319 | 2022 | Details |
Identification of novel diagnostic, predictive and therapeutic strategies in chronic kidney disease
TargetCKD aims to revolutionize chronic kidney disease management by developing noninvasive diagnostics and novel therapeutics through advanced genomic technologies and interdisciplinary research.
Early detection, molecular mechanisms and therapeutic interventions in chronic kidney disease
ELIMINATE-CKD aims to enhance chronic kidney disease detection by developing a method to quantify nephron number using multi-omics and machine learning for improved diagnostics and therapies.
Functional Measurements IN-THE-KIDNEY to Diagnose, Understand and Treat Renal Tubulopathies
This project aims to develop urine-based diagnostics and patient-specific models to enhance understanding and treatment of magnesium-wasting renal tubulopathies through innovative functional studies.
Deciphering the genetic basis of chronic kidney disease towards prevention and personalized therapy
This project aims to uncover the genetic basis of chronic kidney disease (CKD) through next-generation sequencing and develop RNA-based therapies for targeted treatment and improved management.
Decoding diabetic kidney disease
DECODE-DKD aims to identify novel drug targets for diabetic kidney disease through patient-centric multi-omic research and in-vitro models, advancing precision medicine and treatment options.
Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
Kidney Disease Sweat sensor patch for Early diagnosis and Remote MonIToringThe KERMIT project aims to develop a cost-effective, disposable sweat patch for non-invasive early detection and remote monitoring of chronic kidney disease biomarkers. | EIC Pathfinder | € 3.080.623 | 2023 | Details |
breakthrough technologies for an implantable artificial kidneyKIDNEW aims to develop a modular implantable artificial kidney using innovative technologies for improved, cost-effective kidney replacement therapy without immunosuppressive drugs. | EIC Pathfinder | € 3.293.227 | 2023 | Details |
Ontwikkeling van een diagnostische test voor de vroege detectie van chronische nierschadeDit project onderzoekt de ontwikkeling van een niet-invasieve test voor de vroege detectie van chronische nierschade. | Mkb-innovati... | € 18.067 | 2024 | Details |
Haalbaarheid Renal Tracker+Het project onderzoekt de haalbaarheid van de Renal Tracker+, een serviceproduct dat nierpatiënten helpt om de impact van levensstijlveranderingen op hun ziekte te monitoren. | Mkb-innovati... | € 20.000 | 2020 | Details |
Bugs4Urate - Precision Nutrition Strategies for Investigating Probiotic, Diet, Glycan, and Microbiome Factors in Hyperuricemia and Gout PreventionThis project aims to develop a precision nutrition approach using a novel probiotic to lower urate levels and prevent gout by analyzing gut microbiome interactions and individual responses. | EIC Pathfinder | € 3.765.840 | 2024 | Details |
Kidney Disease Sweat sensor patch for Early diagnosis and Remote MonIToring
The KERMIT project aims to develop a cost-effective, disposable sweat patch for non-invasive early detection and remote monitoring of chronic kidney disease biomarkers.
breakthrough technologies for an implantable artificial kidney
KIDNEW aims to develop a modular implantable artificial kidney using innovative technologies for improved, cost-effective kidney replacement therapy without immunosuppressive drugs.
Ontwikkeling van een diagnostische test voor de vroege detectie van chronische nierschade
Dit project onderzoekt de ontwikkeling van een niet-invasieve test voor de vroege detectie van chronische nierschade.
Haalbaarheid Renal Tracker+
Het project onderzoekt de haalbaarheid van de Renal Tracker+, een serviceproduct dat nierpatiënten helpt om de impact van levensstijlveranderingen op hun ziekte te monitoren.
Bugs4Urate - Precision Nutrition Strategies for Investigating Probiotic, Diet, Glycan, and Microbiome Factors in Hyperuricemia and Gout Prevention
This project aims to develop a precision nutrition approach using a novel probiotic to lower urate levels and prevent gout by analyzing gut microbiome interactions and individual responses.