Unprecedented photolithographic structuring of novel light-sensitive poly(amino acid) materials– a paradigm shift in delivering biocompatible devices

Introduction

Photolitography, which produces geometrical structures through light-induced polymerisation of monomers with high accuracy, precision and spatial resolution, was a key innovation enabler in the drive for high-performance miniature electronics. This innovation has had an unprecedented impact on every aspect of our modern life.

Impact on Medical Devices

Geometrically well-defined microstructures could also be a game changer in the medical device industry, especially in the development of implantable devices with better tissue compatibility. Additionally, these structures can play a significant role in the discovery of new drugs and treatments.

Current Limitations

Current gold standard materials and biomaterial extrusion processing cannot generate the structural resolution needed to kick-start this new era.

The POLINA Approach

The groundbreaking approach of POLINA is to combine a radically new, light-sensitive poly(amino acid) material platform with established and emerging photolithographic patterning techniques. This combination aims to deliver a revolutionary technology that can be exploited for:

1. Medical devices
2. Next-generation green electronics

Exploring this uncharted territory will be possible through an ambitious multidisciplinary approach that delivers breakthroughs in photopolymerisation of amino acids and their lithographic structuring for novel materials with unique biological properties.

Demonstration of Innovation Potential

The high innovation potential of this technology to overcome current limitations will be demonstrated in three selected examples related to lung diseases:

1. Micropatterned cell surface models
2. Spheroid arrays for lung disease modelling and drug testing
3. Tracheal implants

Collaborative Expertise

Our intersectoral team of 5 academic groups and 2 SMEs brings together unique scientific expertise in:

• Photo and polymer chemistry
• Biomaterials science
• Lithographic processing
• Tissue engineering
• Clinical expertise
• Innovation management

Through POLINA, we will pave the way to revolutionise bioprinting for safer, smarter, and affordable medical devices, and in the long term, a new approach in (bio)electronics.