Unobtrusive Continuous Multi-Metabolite Monitoring for a Physiological Care of Insulin-treated Diabetes

Introduction

It will be a radically new approach for long-term continuous monitoring of insulin-treated persons with diabetes (ITD) moving from a glucose-only to a multi-metabolite monitoring - glucose, lactate, and 3 OH-butyrate paradigm.

Multi-Metabolite Monitoring

Multi-metabolite monitoring will also lead to a diabetes therapy breakthrough by algorithmically driving a continuous physiologic insulin delivery by a maintenance-free implanted MEMS pump using the peritoneal route. This will enable an optimal therapy for subjects with ITD.

Vision

Our vision is a fully implantable artificial organ to replace insulin secretion loss by targeting metabolic health instead of mere glucose control and mimicking physiological insulin action.

Benefits

While offering a really burden-free life for insulin-treated children and adults, it is expected to allow:

• A dramatic reduction of metabolic variations
• Minimization of acute and long-term complications
• An abating of the still high mortality of T1D patients

Unobtrusive Living

Unobtrusive living with diabetes will be reached by the calibration-free, implantable, long-term multi-metabolite monitoring solution connected wirelessly to a novel highly miniaturized silicon MEMS micropump.

Specifications

• Stroke volume down to 50 nl
• Ability to operate a newly developed U1000 insulin
• Reservoir refill cycles of 180 days up to 365 days

Both devices hold a durable battery operating life of more than 8 years without recharge and are suitable for children.

Control Algorithms

Newly designed control algorithms based upon multiple signal inputs will drive automated insulin delivery without the need for obtrusive meal and physical exercise announcements.