SubsidieMeestersulTRafast hOlograPHic FTIR microscopY
TROPHY combines advanced microscopy techniques to enable rapid, high-resolution imaging of tumor biopsies for precise diagnosis and tailored cancer therapies, enhancing patient outcomes.
Projectdetails
Introduction
Many human pathologies such as cancer are due to complex biochemical alterations that start at a sub-cellular level and lead to progressive changes that result in a heterogeneous tumor composition. The polyclonality of tumor cells hampers the diagnosis and therapy, giving rise to tumor clones that lead to therapy resistance and promote metastases.
Importance of Accurate Diagnosis
An accurate diagnosis of tumor biopsies to identify these particular cell clones is crucial to provide targeted therapy tailored to the tumor characteristics. This approach aims to improve patient outcomes and increase survival rates.
Introduction of TROPHY
For this vision to come true, we introduce ulTRafast hOlograPHic FT-IR microscopY (TROPHY) as a paradigm shift in vibrational microscopy. TROPHY blends elements of:
- Photo-thermal infrared (PT-IR)
- Fourier transform (FT)-IR
- Digital Holography Microscopy (DHM)
Technological Advancements
TROPHY brings these techniques to the unprecedented ultrafast timescale, where the refractive index change induced by coherent IR vibrations is probed at its peak value before thermal relaxation.
TROPHY borrows from:
- PT-IR the combination of IR vibrational excitation with visible probing for high spatial resolution
- FT-IR the use of time-domain interferometry to obtain high spectral resolution from broadband excitation
- DHM highly sensitive and quantitative detection of the refractive index (phase) change
Integration with Artificial Intelligence
Combined with artificial intelligence algorithms, this technology will enable quantitative concentration imaging of molecular biomarkers with:
- High spatial resolution
- High chemical selectivity
- High speed
This integration will have a transformative impact on medical research and clinics.
Application in Oncology
In oncology, TROPHY will be applied to intraoperative diagnosis of tumor biopsies, providing:
- Tumor grading
- Staging
- Subtyping
This technology will support complete tumor resection and allow for the determination of the best therapeutic approach tailored to the patient. Additionally, it will help identify resistant tumor clones under targeted therapy, paving the way for precision medicine in cancer.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 1.904.544 |
| Totale projectbegroting | € 1.904.544 |
Tijdlijn
| Startdatum | 1-9-2022 |
| Einddatum | 31-8-2026 |
| Subsidiejaar | 2022 |
Partners & Locaties
Projectpartners
- POLITECNICO DI MILANOpenvoerder
- FUNDACIO INSTITUT DE CIENCIES FOTONIQUES
- CONSIGLIO NAZIONALE DELLE RICERCHE
- UNIVERSITATSKLINIKUM JENA
- LYNCEE TEC SA
- THE UNIVERSITY OF EXETER
- THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Land(en)
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