NATURAL INTRAOCULAR PHOTOACTIVATION OF COMPOUNDS TO FIGHT RETINOPATHIES

Introduction

Retinopathies constitute an extreme societal and socioeconomic burden that is expected to increase with an aging population and the increased prevalence of diabetes. These diseases, including age-related macular degeneration and proliferative diabetic retinopathy, share neovascularization as a common etiology involving the pathological growth of retinal capillaries leading to blindness if left untreated.

Current Treatment Modalities

Current treatment modalities involve specialized injections into the eye that require not only outpatient visits to specialized treatment centers but are also associated with significant adverse effects.

Potential of Orally Bioavailable Medications

Orally bioavailable medications could revolutionize the treatment of retinopathies by:

• Reducing adverse effects
• Sustaining vision
• Lowering the direct and indirect financial burden associated with these diseases
• Increasing access to healthcare

Novel Drug Targeting Approach

Inspired by this idea, we have developed an approach that can be exploited to target essentially any therapeutic molecule to the eye. Our novel strategy of drug targeting will:

• Enrich the modified molecules in retinal tissue
• Reduce the therapeutic oral dose compared to existing anti-angiogenic therapy in cancer, thereby increasing the safety of the treatment

This is achieved by absorbing a minute amount of the chemically and biologically stable molecules, resulting in an extremely low plasma concentration and relying on a biological mechanism in the eye to activate the molecules to tether them to retinal target receptors and thereby extract them from the blood.

Proof-of-Concept Proposal

In the present application, we propose to demonstrate proof-of-concept of this strategy by modifying inhibitors of the vascular endothelial growth factor receptor (VEGFR). VEGFR is an endothelial receptor tyrosine kinase that is a key mediator of angiogenesis and an established drug target for the treatment of retinopathies.

Future Implications

Our approach will elicit a paradigm shift in how we design future drug delivery strategies to the retina.