SubsidieMeestersThe critical shift to single-cell formats in functional analyses of living cells
Samplix is developing Xplore, a cost-effective single-cell analyser and sorter to enhance immune cell analysis, supporting faster development of personalized therapies for serious diseases.
Projectdetails
Introduction
The incredible potential of cell and immune therapy (CIT) is limited by technical challenges related to the standard analysis of immune cells in bulk, which neglects their heterogeneity.
Importance of Single-Cell Analysis
Single-cell functional resolution is essential to understand the full potential of immune cells. Current single-cell technologies are limited, low-throughput, high-cost, and lack robustness, which is prohibitive for their implementation in CIT R&D, manufacturing, and patient stratification.
Development of Xplore
Samplix is developing Xplore, an all-in-one multiparameter single-cell analyser and sorter for screening, selection, and expansion of immune cells based on functionality and potency.
Advantages of Xplore
Xplore is a cost-effective solution that delivers higher throughput and sensitivity than current solutions, being compatible with CIT research workflows.
Impact on Personalized Therapies
Unlocking the full potential of CIT supports the faster and efficient development of new personalized therapies to treat serious diseases such as cancer, autoimmune diseases, and viral infections.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 2.500.000 |
| Totale projectbegroting | € 4.926.042 |
Tijdlijn
| Startdatum | 1-8-2023 |
| Einddatum | 31-7-2025 |
| Subsidiejaar | 2023 |
Partners & Locaties
Projectpartners
- SAMPLIX ApSpenvoerder
Land(en)
Vergelijkbare projecten binnen EIC Accelerator
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
IOO: a novel assay to predict patient response to immune checkpoint inhibitors, optimising patient stratification to these therapies and tripling solid tumour patient outcomes in immuno-oncology.The project aims to enhance cancer immunotherapy efficacy by developing a validated biomarker assay to predict patient responses, potentially doubling survival rates for lethal tumors. | EIC Accelerator | € 2.496.112 | 2024 | Details |
Multi-organ toxicity and efficacy test platform for Personalized medicine & Drug developmentCherry Biotech aims to revolutionize drug development and personalized medicine by providing a patented 3D cell culture platform that enhances predictability and reduces reliance on animal testing. | EIC Accelerator | € 2.499.831 | 2024 | Details |
Development and validation of the first digital, clinical grade flow cytometry platform for enhanced diagnosis accuracy and sustainability in immunology and hemato oncologyMETAflow aims to revolutionize clinical flow cytometry by providing an automated, user-friendly platform for comprehensive data analysis, enhancing usability and robustness in diagnostics. | EIC Accelerator | € 2.499.579 | 2023 | Details |
IOO: a novel assay to predict patient response to immune checkpoint inhibitors, optimising patient stratification to these therapies and tripling solid tumour patient outcomes in immuno-oncology.
The project aims to enhance cancer immunotherapy efficacy by developing a validated biomarker assay to predict patient responses, potentially doubling survival rates for lethal tumors.
Multi-organ toxicity and efficacy test platform for Personalized medicine & Drug development
Cherry Biotech aims to revolutionize drug development and personalized medicine by providing a patented 3D cell culture platform that enhances predictability and reduces reliance on animal testing.
Development and validation of the first digital, clinical grade flow cytometry platform for enhanced diagnosis accuracy and sustainability in immunology and hemato oncology
METAflow aims to revolutionize clinical flow cytometry by providing an automated, user-friendly platform for comprehensive data analysis, enhancing usability and robustness in diagnostics.
Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
Multidimensional in vivo metabolic flux analyses: Resolving immune cells based on in vivo metabolic phenotypesThe project aims to develop a novel nutrient uptake assay for analyzing immune cell metabolism in vivo, enhancing immunotherapy design for solid tumors through detailed metabolic insights. | ERC Proof of... | € 150.000 | 2023 | Details |
Functional Cell SorterDit project richt zich op het karakteriseren en sorteren van individuele cellen op functie om moleculaire eigenschappen te koppelen, wat de ontwikkeling van medicijnen en ziekteonderzoek bevordert. | Mkb-innovati... | € 185.500 | 2017 | Details |
Precision Diagnostics for Predicting Therapy Response to Bispecific AntibodiesThis project aims to develop a precision diagnostic tool that predicts responses to bispecific antibody therapies by mapping single-cell immune interactions in children with acute lymphoblastic leukemia. | ERC Proof of... | € 150.000 | 2025 | Details |
Developing novel single-cell technologies to model and perturb intra-tumor interactions and signaling – an innovation program for the next generation of immunotherapiesThe TROJAN-Cell project aims to engineer immune responses against tumors by understanding immune-suppressive mechanisms in the tumor microenvironment using advanced single-cell technologies. | ERC Advanced... | € 2.500.000 | 2022 | Details |
Super-resolution microscopy for immune checkpoint inhibitors diagnosticsNANODIAGNOSTIC aims to translate super-resolution microscopy techniques into clinical tools for cancer diagnostics, enhancing patient stratification for effective immunotherapy. | ERC Proof of... | € 150.000 | 2022 | Details |
Multidimensional in vivo metabolic flux analyses: Resolving immune cells based on in vivo metabolic phenotypes
The project aims to develop a novel nutrient uptake assay for analyzing immune cell metabolism in vivo, enhancing immunotherapy design for solid tumors through detailed metabolic insights.
Functional Cell Sorter
Dit project richt zich op het karakteriseren en sorteren van individuele cellen op functie om moleculaire eigenschappen te koppelen, wat de ontwikkeling van medicijnen en ziekteonderzoek bevordert.
Precision Diagnostics for Predicting Therapy Response to Bispecific Antibodies
This project aims to develop a precision diagnostic tool that predicts responses to bispecific antibody therapies by mapping single-cell immune interactions in children with acute lymphoblastic leukemia.
Developing novel single-cell technologies to model and perturb intra-tumor interactions and signaling – an innovation program for the next generation of immunotherapies
The TROJAN-Cell project aims to engineer immune responses against tumors by understanding immune-suppressive mechanisms in the tumor microenvironment using advanced single-cell technologies.
Super-resolution microscopy for immune checkpoint inhibitors diagnostics
NANODIAGNOSTIC aims to translate super-resolution microscopy techniques into clinical tools for cancer diagnostics, enhancing patient stratification for effective immunotherapy.