SubsidieMeestersNAO.VNS: A New Personalized Neural Stimulation Therapy For Drug-resistant Epilepsy
NAO.VNS is an innovative implantable vagus nerve stimulator using optical fibers to enhance treatment for drug-resistant epilepsy, enabling personalized therapy and remote monitoring, with market approval expected by 2028.
Projectdetails
Introduction
19.5M world population suffer from Drug-Resistant Epilepsy (DRE) with symptoms poorly controlled. 8M are not eligible for brain surgery. Vagus nerve stimulation is nowadays the best treatment option. But unfortunately, current solutions do not reply to the clinical need. They cannot adapt to each patient, making the patient's therapeutic journey complicated and expensive.
Project Overview
We created NAO.VNS, the next-generation implantable vagus nerve neurostimulator. We replaced metal wires with optical fibres to convert optical energy to electrical impulses, rendering the device compliant with MRI & brain scans essential for disease diagnosis or treatment.
Benefits of NAO.VNS
Through NAO.VNS, patients and physicians receive remote feedback on the direct effect and efficacy of the neural stimulation, allowing for precise and unique adaptation of therapy.
Funding and Future Plans
Through EIC funding, we will complete a clinical pilot trial and a pivotal study in the EU/US to initiate market approvals.
Financial Projections
We expect to generate 89M by 2028 from sales in the EU/US.
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 2.499.000 |
| Totale projectbegroting | € 4.471.250 |
Tijdlijn
| Startdatum | 1-3-2023 |
| Einddatum | 31-8-2025 |
| Subsidiejaar | 2023 |
Partners & Locaties
Projectpartners
- SYNERGIA MEDICALpenvoerder
Land(en)
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Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
Revolutionizing diabetes management by combining in silico models and AI control for vagus neuroprosthesesThe project aims to develop a personalized Vagus Nerve Stimulation neuroprosthesis for automated glucose regulation in diabetics, utilizing AI to optimize stimulation and minimize side effects. | ERC Consolid... | € 1.999.201 | 2025 | Details |
First Closed-loop non-Invasive Seizure Prevention SystemProject RELIEVE aims to develop a non-invasive closed-loop system using AI and wearable ultrasound for real-time monitoring and intervention in brain disorders, starting with epilepsy treatment. | EIC Pathfinder | € 2.809.260 | 2023 | Details |
Bidirectional neuromuscular interface based on associative plasticity for stroke therapy during activities of daily livingThe neubond device offers autonomous, wearable therapy for stroke recovery, enhancing motor function and neuroplasticity through real-time muscle stimulation during daily activities. | ERC Proof of... | € 150.000 | 2025 | Details |
Injectable nanoelectrodes for wireless and minimally invasive neural stimulationDeveloping minimally invasive, nanoscale, wireless neuroelectrodes for targeted neural stimulation to improve treatment accessibility for neurological impairments. | ERC Starting... | € 1.499.725 | 2023 | Details |
Minimally invasive and closed-loop ultrasound neuromodulation and recording for the treatment of focal epilepsyThis project aims to develop a minimally invasive, closed-loop ultrasound neuromodulation system for treating refractory epilepsy, optimizing protocols through a comprehensive computational framework. | ERC Starting... | € 1.499.575 | 2025 | Details |
Revolutionizing diabetes management by combining in silico models and AI control for vagus neuroprostheses
The project aims to develop a personalized Vagus Nerve Stimulation neuroprosthesis for automated glucose regulation in diabetics, utilizing AI to optimize stimulation and minimize side effects.
First Closed-loop non-Invasive Seizure Prevention System
Project RELIEVE aims to develop a non-invasive closed-loop system using AI and wearable ultrasound for real-time monitoring and intervention in brain disorders, starting with epilepsy treatment.
Bidirectional neuromuscular interface based on associative plasticity for stroke therapy during activities of daily living
The neubond device offers autonomous, wearable therapy for stroke recovery, enhancing motor function and neuroplasticity through real-time muscle stimulation during daily activities.
Injectable nanoelectrodes for wireless and minimally invasive neural stimulation
Developing minimally invasive, nanoscale, wireless neuroelectrodes for targeted neural stimulation to improve treatment accessibility for neurological impairments.
Minimally invasive and closed-loop ultrasound neuromodulation and recording for the treatment of focal epilepsy
This project aims to develop a minimally invasive, closed-loop ultrasound neuromodulation system for treating refractory epilepsy, optimizing protocols through a comprehensive computational framework.