SubsidieMeestersFirst time ultra-sensitive and simultaneous quantification of proteins, interactions, and post-translational modifications in single cells to enable exponential growth in proteomics and interactomics
PICO-NGS aims to revolutionize proteomics by enabling ultra-sensitive, high-parallel measurement of proteins, interactions, and modifications, accelerating advancements in various industries.
Projectdetails
Introduction
In a human cell, there are about 20k protein coding genes (genome) that originate ~100k proteins (proteome). Proteins are involved in complex networks of protein-protein interactions (PPIs) influenced by post-translational modifications (PTMs), the interactome of living cells (~800,000 entities).
Genome and Proteome
The genome is mostly static throughout the cell's lifetime and can be sequenced today in less than 1 hour. The proteome and interactome are changing with factors such as environment and health, and they are not yet fully known.
Current Challenges
Today's methods for proteomics and interactomics are tedious and lack:
- Sensitivity
- Quantitativity
- Parallelism
PICO-NGS Solution
PICO-NGS combines ultra-high sensitivity (>10 fM) with high parallelism, measuring proteins, PPIs, and PTMs simultaneously (>50 targets).
Market Impact
This innovation will disrupt the global proteomics market, which is valued at 29 billion USD with a 16% CAGR.
Future Applications
PICO-NGS will fertilize groundbreaking academic research and accelerate developments in various industries, including:
- Pharma (drug discovery)
- Biotech (biomarkers/diagnosis)
- Agrotech (crop sciences)
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 2.498.125 |
| Totale projectbegroting | € 3.568.750 |
Tijdlijn
| Startdatum | 1-8-2023 |
| Einddatum | 31-7-2025 |
| Subsidiejaar | 2023 |
Partners & Locaties
Projectpartners
- ACTOME GMBHpenvoerder
Land(en)
Vergelijkbare projecten binnen EIC Accelerator
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|---|---|---|---|---|
The ProM platform: New ways to drug the undruggablePROSION's ProM-platform aims to unlock and target the undruggable 85% of the human proteome, developing new therapies for hard-to-treat diseases like cancer. | EIC Accelerator | € 2.461.375 | 2022 | Details |
The ProM platform: New ways to drug the undruggable
PROSION's ProM-platform aims to unlock and target the undruggable 85% of the human proteome, developing new therapies for hard-to-treat diseases like cancer.
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