SubsidieMeestersFirst time ultra-sensitive and simultaneous quantification of proteins, interactions, and post-translational modifications in single cells to enable exponential growth in proteomics and interactomics
PICO-NGS aims to revolutionize proteomics by enabling ultra-sensitive, high-parallel measurement of proteins, interactions, and modifications, accelerating advancements in various industries.
Projectdetails
Introduction
In a human cell, there are about 20k protein coding genes (genome) that originate ~100k proteins (proteome). Proteins are involved in complex networks of protein-protein interactions (PPIs) influenced by post-translational modifications (PTMs), the interactome of living cells (~800,000 entities).
Genome and Proteome Dynamics
The genome is mostly static throughout cell lifetime and can be sequenced today in less than 1 hour. In contrast, the proteome and interactome are changing with factors such as environment and health, and they are not yet fully known.
Current Challenges in Proteomics and Interactomics
Today's methods for proteomics and interactomics are tedious and lack:
- Sensitivity
- Quantitativity
- Parallelism
PICO-NGS Innovation
PICO-NGS combines ultra-high sensitivity (>10 fM) with high parallelism, measuring proteins, PPIs, and PTMs simultaneously (>50 targets).
Market Impact
This innovation will disrupt the global proteomics market, which is worth $29 billion with a 16% CAGR.
Applications in Various Industries
PICO-NGS will fertilize groundbreaking academic research and accelerate developments in various industries, including:
- Pharma (drug discovery)
- Biotech (biomarkers/diagnosis)
- Agrotech (crop sciences)
Financiële details & Tijdlijn
Financiële details
| Subsidiebedrag | € 2.498.125 |
| Totale projectbegroting | € 3.568.750 |
Tijdlijn
| Startdatum | 1-8-2023 |
| Einddatum | 31-7-2025 |
| Subsidiejaar | 2023 |
Partners & Locaties
Projectpartners
- ACTOME GMBHpenvoerder
Land(en)
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A new cardioprotective drug for acute treatment of myocardial infarction
ResoTher aims to validate RTP-026, an immunomodulating therapy, to reduce heart damage and HF risk post-myocardial infarction through Phase II clinical studies.
Clear, scalable and scientific framework to measure terrestrial biodiversity
3Bee leverages IoT, wildlife monitoring, and satellite data to measure and regenerate biodiversity, generating certified Biodiversity Credits for corporations to enhance ESG reporting and brand value.
Novel and Scalable microbial products for REgenerative agriculture
N-Spire aims to revolutionize agriculture by creating a sustainable bioactive fertilizer through innovative manufacturing techniques, enhancing soil health and reducing chemical dependency.
Quantum-based Randomness Processing Units (RPUs) for High-Performance Computation and Data Security
Quside's Randomness Processing Unit (RPU) accelerates stochastic HPC and PQ cryptography by optimizing random workloads, enhancing efficiency and performance across various sectors.
Vergelijkbare projecten uit andere regelingen
| Project | Regeling | Bedrag | Jaar | Actie |
|---|---|---|---|---|
Proteomic Analysis of Cell communication in TumorsThis project aims to analyze cancer proteome dynamics at single-cell resolution to understand tumor heterogeneity and improve personalized treatment for resistant metastatic cells. | ERC COG | € 2.000.000 | 2022 | Details |
Single-Molecule Acousto-Photonic NanofluidicsSIMPHONICS aims to develop a high-throughput, non-invasive platform for protein fingerprinting by integrating nanopore technology with acoustic manipulation and fluorescence detection. | ERC STG | € 1.499.395 | 2022 | Details |
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Proteome-wide Functional Interrogation and Modulation of Gut Microbiome SpeciesThis project aims to identify and manipulate gut microbiome protein functions using high-throughput proteomics to develop targeted therapies for restoring microbial health. | ERC STG | € 1.499.980 | 2023 | Details |
Proteomic Analysis of Cell communication in Tumors
This project aims to analyze cancer proteome dynamics at single-cell resolution to understand tumor heterogeneity and improve personalized treatment for resistant metastatic cells.
Single-Molecule Acousto-Photonic Nanofluidics
SIMPHONICS aims to develop a high-throughput, non-invasive platform for protein fingerprinting by integrating nanopore technology with acoustic manipulation and fluorescence detection.
Learning Isoform Fingerprints to Discover the Molecular Diversity of Life
This project aims to revolutionize proteomics by developing a novel data analysis strategy using deep learning to discover and quantify protein isoforms through their unique multi-dimensional fingerprints (ORIGINs).
Proteome-wide Functional Interrogation and Modulation of Gut Microbiome Species
This project aims to identify and manipulate gut microbiome protein functions using high-throughput proteomics to develop targeted therapies for restoring microbial health.